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Stanford Medicine study shows why mRNA COVID-19 vaccine can cause myocarditis, P5


December 10, 2025

Updated on: June 29, 2026

Photo / Image Source: Unsplash,


Vaccine-associated myocarditis occurs in about one in every 140,000 vaccinees after a first dose and rises to one in 32,000 after a second dose. For reasons that aren’t clear, incidence peaks among male vaccinees age 30 or below, at one in 16,750 vaccinees.

Fortunately, most of these cases end well, Wu said, with full heart function retained or restored.  Recovery is typically swift.

“It’s not a heart attack in the traditional sense,” he said. “There’s no blockage of blood vessels as found in most common heart attacks. When symptoms are mild and the inflammation hasn’t caused structural damage to the heart, we just observe these patients to make sure they recover.”

However, Wu noted, if the inflammation is severe the resulting heart injury can be quite debilitating, leading to hospitalizations; ICU admissions for critically ill patients; and deaths, albeit rarely.

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