Stanford Medicine study shows why mRNA COVID-19 vaccine can cause myocarditis, P17
December 10, 2025
Updated on: June 29, 2026
Source: Sranford University
Photo / Image Source: Unsplash,
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Elevated inflammatory cytokine signaling could be a class effect of mRNA vaccines. Notably, IFN-gamma signaling is a fundamental defense mechanism against foreign DNA and RNA molecules, including viral nucleic acids, Wu said.
“Your body needs these cytokines to ward off viruses. It’s essential to immune response but can become toxic in large amounts,” he said. IFN-gamma secreted in large amounts, however lofty its purpose, can trigger myocarditis-like symptoms and degradation of structural heart muscle proteins.
That risk probably extends beyond mRNA-based COVID-19 vaccines.

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