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Stanford Medicine study shows why mRNA COVID-19 vaccine can cause myocarditis, P2


December 10, 2025

Updated on: June 29, 2026

Photo / Image Source: Unsplash,


tanford Medicine investigators have unearthed the biological process by which mRNA-based vaccines for COVID-19 can cause heart damage in some young men and adolescents — and they’ve shown a possible route to reducing its likelihood.

Using advanced but now common lab technologies, along with published data from vaccinated individuals, the researchers identified a two-step sequence in which these vaccines activate a certain type of immune cell, in turn riling up another type of immune cell. The resulting inflammatory activity directly injures heart muscle cells, while triggering further inflammatory damage.

The mRNA vaccines for COVID-19, which have now been administered several billion times, have been heavily scrutinized for safety and have been shown to be extremely safe, said Joseph Wu, MD, PhD, the director of the Stanford Cardiovascular Institute.

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